27/08/2025
Did you know? The negative effects of cardiovascular risk factors (like high blood pressure, diabetes, high cholesterol, smoking, obesity, excessive alcohol consumption) on the brain, are strongest when they occur in midlife (roughly ages 40–65).
In other words, if these risks are present during your midlife, they cause the most damage to brain health and significantly increase the chances of developing cognitive decline or dementia later in life.
Essentially, dementia does not typically start at the age of 65 years and beyond. The damage often begins around age 40 or so.
Ref:
Schott JM. Lifestyle Interventions to Improve Cognition in Later Life: When Is Enough Enough? JAMA. 2025;334(8):674–676. doi:10.1001/jama.2025.12500