UKM Medical Molecular Biology Institute - UMBI

UKM Medical Molecular Biology Institute - UMBI UMBI was formed in July 2003 as one of the strategies by the university to enhance research in molecular medicine.

UMBI has grown in strength over the years and is now recognised as a Higher Institution Centre of Excellence (HICoE) by the Ministry of Higher Education, a status conferred to only 6 centres of excellence in research in the nation. For the HICoE critical agenda program, UMBI is focusing on cancer biomarkers. UMBI has key laboratories providing platform technologies and analysis in genomics, transcriptomics and proteomics.

๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐’๐ฉ๐จ๐ญ๐ฅ๐ข๐ ๐ก๐ญ ๐๐จ.๐Ÿ“/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”๐’๐ข๐ฅ๐ž๐ง๐ญ ๐‘๐ž๐ฌ๐ž๐ซ๐ฏ๐จ๐ข๐ซ๐ฌ: ๐Œ๐ž๐ญ๐ก๐ข๐œ๐ข๐ฅ๐ฅ๐ข๐ง-๐‘๐ž๐ฌ๐ข๐ฌ๐ญ๐š๐ง๐ญ ๐’๐ญ๐š๐ฉ๐ก๐ฒ๐ฅ๐จ๐œ๐จ๐œ๐œ๐ข (๐Œ๐‘๐’) ๐ข๐ง ๐Œ๐ข๐ ๐ซ๐š๐ง๐ญ ๐‚๐จ๐ฆ๐ฆ๐ฎ๐ง๐ข๐ญ๐ข๐ž๐ฌUMBI...
08/06/2026

๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐’๐ฉ๐จ๐ญ๐ฅ๐ข๐ ๐ก๐ญ ๐๐จ.๐Ÿ“/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”

๐’๐ข๐ฅ๐ž๐ง๐ญ ๐‘๐ž๐ฌ๐ž๐ซ๐ฏ๐จ๐ข๐ซ๐ฌ: ๐Œ๐ž๐ญ๐ก๐ข๐œ๐ข๐ฅ๐ฅ๐ข๐ง-๐‘๐ž๐ฌ๐ข๐ฌ๐ญ๐š๐ง๐ญ ๐’๐ญ๐š๐ฉ๐ก๐ฒ๐ฅ๐จ๐œ๐จ๐œ๐œ๐ข (๐Œ๐‘๐’) ๐ข๐ง ๐Œ๐ข๐ ๐ซ๐š๐ง๐ญ ๐‚๐จ๐ฆ๐ฆ๐ฎ๐ง๐ข๐ญ๐ข๐ž๐ฌ

UMBI is pleased to share a published scientific report arising from the PhD research of ๐Œ๐ฌ. ๐๐ฎ๐ซ๐ฎ๐ฅ ๐€๐ฆ๐ข๐ซ๐š๐ก ๐Œ๐จ๐ก๐š๐ฆ๐š๐ ๐…๐š๐ซ๐จ๐จ๐ค under the supervision of ๐€๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ž ๐๐ซ๐จ๐Ÿ๐ž๐ฌ๐ฌ๐จ๐ซ ๐ƒ๐ซ. ๐๐ž๐จ๐ก ๐‡๐ฎ๐ข-๐ฆ๐ข๐ง. Published in IJID Regions, the study examines the nasal carriage of antibiotic-resistant bacteria among migrant workers from Indonesia, Bangladesh, and Nepal living in Malaysia's Klang Valley, highlighting an important but often overlooked public health issue affecting migrant worker communities in the country.

A total of ๐Ÿ๐Ÿ“๐Ÿ– ๐ก๐ž๐š๐ฅ๐ญ๐ก๐ฒ ๐ข๐ง๐๐ข๐ฏ๐ข๐๐ฎ๐š๐ฅ๐ฌ ๐ฐ๐ž๐ซ๐ž ๐ฌ๐œ๐ซ๐ž๐ž๐ง๐ž๐, revealing that nearly ๐Ÿ๐Ÿ“% ๐œ๐š๐ซ๐ซ๐ข๐ž๐ ๐ฆ๐ž๐ญ๐ก๐ข๐œ๐ข๐ฅ๐ฅ๐ข๐ง-๐ซ๐ž๐ฌ๐ข๐ฌ๐ญ๐š๐ง๐ญ ๐ฌ๐ญ๐š๐ฉ๐ก๐ฒ๐ฅ๐จ๐œ๐จ๐œ๐œ๐ข (๐Œ๐‘๐’), underscoring the potential role of healthy carriers as silent reservoirs for antibiotic-resistant bacteria within the community. Distinct MRS species dominance was also observed among different nationalities. The study further identified a significant link between ๐จ๐ฏ๐ž๐ซ๐œ๐ซ๐จ๐ฐ๐๐ž๐ ๐ก๐จ๐ฎ๐ฌ๐ข๐ง๐  ๐œ๐จ๐ง๐๐ข๐ญ๐ข๐จ๐ง๐ฌ and the presence of these pathogens, particularly among workers employed in the ๐๐จ๐ฆ๐ž๐ฌ๐ญ๐ข๐œ ๐š๐ง๐ ๐ฆ๐š๐ง๐ฎ๐Ÿ๐š๐œ๐ญ๐ฎ๐ซ๐ข๐ง๐  ๐ฌ๐ž๐œ๐ญ๐จ๐ซ๐ฌ. Molecular analysis showed that many bacterial isolates exhibited ๐ฆ๐ฎ๐ฅ๐ญ๐ข๐๐ซ๐ฎ๐  ๐ซ๐ž๐ฌ๐ข๐ฌ๐ญ๐š๐ง๐œ๐ž, raising concerns for silent transmission within the community. These findings emphasize the need for better ๐ก๐ž๐š๐ฅ๐ญ๐ก ๐ฌ๐ฎ๐ซ๐ฏ๐ž๐ข๐ฅ๐ฅ๐š๐ง๐œ๐ž and improved living standards for migrant populations to manage public health risks. Ultimately, the source serves as the first investigation into how ๐ฌ๐จ๐œ๐ข๐จ๐ž๐œ๐จ๐ง๐จ๐ฆ๐ข๐œ ๐Ÿ๐š๐œ๐ญ๐จ๐ซ๐ฌ may contribute to the spread of resistant staphylococci among these communities in Malaysia.

These findings further demonstrate UMBIโ€™s growing contribution to translational and community-focused molecular medicine research, particularly in understanding antimicrobial resistance, pathogen transmission, and population health challenges affecting vulnerable communities.

Read the full article to learn more about the study findings, antibiotic resistance patterns, and their implications for public health research in Malaysia.

5 June 2026 | This morning's ๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐”๐ฉ๐๐š๐ญ๐ž ๐’๐ž๐ซ๐ข๐ž๐ฌ ๐ข๐ง ๐Œ๐จ๐ฅ๐ž๐œ๐ฎ๐ฅ๐š๐ซ ๐Œ๐ž๐๐ข๐œ๐ข๐ง๐ž ๐๐จ. ๐Ÿ๐Ÿ’/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ” featured an insightful presen...
05/06/2026

5 June 2026 | This morning's ๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐”๐ฉ๐๐š๐ญ๐ž ๐’๐ž๐ซ๐ข๐ž๐ฌ ๐ข๐ง ๐Œ๐จ๐ฅ๐ž๐œ๐ฎ๐ฅ๐š๐ซ ๐Œ๐ž๐๐ข๐œ๐ข๐ง๐ž ๐๐จ. ๐Ÿ๐Ÿ’/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ” featured an insightful presentation by ๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐…๐ž๐ฅ๐ฅ๐จ๐ฐ, ๐ƒ๐ซ. ๐’๐ข๐ญ๐ข ๐€๐ข๐ฌ๐ก๐š๐ก ๐’๐ฎ๐ฅ๐š๐ข๐ฆ๐š๐ง, entitled โ€œFatty Liver: Thin Doesn't Mean Immuneโ€.

The session highlighted fatty liver disease as a growing global health concern and a silent epidemic, with prevalence continuing to rise worldwide. Dr. Aishah shared that the global prevalence reached approximately 38% in 2022, affecting an estimated 3 billion individuals, while more than 30% of the population in South-East Asia is affected. In Malaysia, findings from the ๐๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐‡๐ž๐š๐ฅ๐ญ๐ก ๐š๐ง๐ ๐Œ๐จ๐ซ๐›๐ข๐๐ข๐ญ๐ฒ ๐’๐ฎ๐ซ๐ฏ๐ž๐ฒ (๐๐‡๐Œ๐’) ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ‘ indicate that approximately 28% of Malaysians have fatty liver disease.

A key focus of the presentation was the often-overlooked phenomenon of Lean MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease), where ๐ข๐ง๐๐ข๐ฏ๐ข๐๐ฎ๐š๐ฅ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐š ๐ง๐จ๐ซ๐ฆ๐š๐ฅ ๐›๐จ๐๐ฒ ๐ฆ๐š๐ฌ๐ฌ ๐ข๐ง๐๐ž๐ฑ (๐๐Œ๐ˆ) ๐ฆ๐š๐ฒ ๐ฌ๐ญ๐ข๐ฅ๐ฅ ๐๐ž๐ฏ๐ž๐ฅ๐จ๐ฉ ๐Ÿ๐š๐ญ๐ญ๐ฒ ๐ฅ๐ข๐ฏ๐ž๐ซ. The audience was introduced to the concept of ๐“๐Ž๐…๐ˆ (๐“๐ก๐ข๐ง ๐Ž๐ฎ๐ญ๐ฌ๐ข๐๐ž, ๐…๐š๐ญ ๐ˆ๐ง๐ฌ๐ข๐๐ž), describing individuals with relatively low subcutaneous fat but high levels of visceral fat, which may increase MASLD risk despite appearing lean. Dr. Aishah also discussed the ๐ฉ๐จ๐ญ๐ž๐ง๐ญ๐ข๐š๐ฅ ๐ซ๐จ๐ฅ๐ž ๐จ๐Ÿ ๐ญ๐ก๐ž ๐๐๐๐‹๐€๐Ÿ‘๐ˆ๐Ÿ๐Ÿ’๐Ÿ–๐Œ ๐ ๐ž๐ง๐ž๐ญ๐ข๐œ ๐ฏ๐š๐ซ๐ข๐š๐ง๐ญ ๐ข๐ง ๐‹๐ž๐š๐ง ๐Œ๐€๐’๐‹๐ƒ ๐ฌ๐ฎ๐ฌ๐œ๐ž๐ฉ๐ญ๐ข๐›๐ข๐ฅ๐ข๐ญ๐ฒ.

The presentation further explored the differences between obese and lean MASLD profiles, highlighting current clinical challenges and the tendency for ๐‹๐ž๐š๐ง ๐Œ๐€๐’๐‹๐ƒ ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ๐ฌ ๐ญ๐จ ๐›๐ž ๐ฎ๐ง๐๐ž๐ซ-๐ฌ๐œ๐ซ๐ž๐ž๐ง๐ž๐ ๐๐ฎ๐ž ๐ญ๐จ ๐ฉ๐ซ๐ž๐ฏ๐š๐ข๐ฅ๐ข๐ง๐  ๐œ๐ฅ๐ข๐ง๐ข๐œ๐š๐ฅ ๐›๐ข๐š๐ฌ ๐ญ๐ก๐š๐ญ ๐š๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ž๐ฌ ๐Ÿ๐š๐ญ๐ญ๐ฒ ๐ฅ๐ข๐ฏ๐ž๐ซ ๐ฉ๐ซ๐ข๐ฆ๐š๐ซ๐ข๐ฅ๐ฒ ๐ฐ๐ข๐ญ๐ก ๐จ๐›๐ž๐ฌ๐ข๐ญ๐ฒ.

The session concluded with an engaging Q&A discussion, reflecting strong interest from participants. Appreciation is extended to Dr. Aishah for her informative sharing and to all attendees for their active participation and insightful questions.

๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐’๐ฉ๐จ๐ญ๐ฅ๐ข๐ ๐ก๐ญ ๐๐จ.๐Ÿ’/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”๐ƒ๐ž๐œ๐จ๐๐ข๐ง๐  ๐ญ๐ก๐ž ๐‘๐จ๐ฅ๐ž๐ฌ ๐จ๐Ÿ ๐“๐†๐…ฮฒ ๐ˆ๐ฌ๐จ๐Ÿ๐จ๐ซ๐ฆ๐ฌ ๐ข๐ง ๐“๐ซ๐ข๐ฉ๐ฅ๐ž-๐๐ž๐ ๐š๐ญ๐ข๐ฏ๐ž ๐๐ซ๐ž๐š๐ฌ๐ญ ๐‚๐š๐ง๐œ๐ž๐ซ (๐“๐๐๐‚)UMBI is plea...
02/06/2026

๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐’๐ฉ๐จ๐ญ๐ฅ๐ข๐ ๐ก๐ญ ๐๐จ.๐Ÿ’/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”

๐ƒ๐ž๐œ๐จ๐๐ข๐ง๐  ๐ญ๐ก๐ž ๐‘๐จ๐ฅ๐ž๐ฌ ๐จ๐Ÿ ๐“๐†๐…ฮฒ ๐ˆ๐ฌ๐จ๐Ÿ๐จ๐ซ๐ฆ๐ฌ ๐ข๐ง ๐“๐ซ๐ข๐ฉ๐ฅ๐ž-๐๐ž๐ ๐š๐ญ๐ข๐ฏ๐ž ๐๐ซ๐ž๐š๐ฌ๐ญ ๐‚๐š๐ง๐œ๐ž๐ซ (๐“๐๐๐‚)

UMBI is pleased to share a recent publication from our researchers, led by ๐ƒ๐ซ. ๐„๐ณ๐š๐ง๐ž๐ž ๐€๐ณ๐ฅ๐ข๐ง๐š ๐Œ๐จ๐ก๐š๐ฆ๐š๐ ๐‡๐š๐ง๐ข๐Ÿ, exploring the distinct molecular roles of TGFฮฒ isoforms in triple-negative breast cancer (TNBC), one of the most aggressive and treatment-challenging breast cancer subtypes.

Using transcriptomic analysis of 486 TNBC patient samples, the study revealed that ๐“๐†๐…ฮฒ๐Ÿ, ๐“๐†๐…ฮฒ๐Ÿ, ๐š๐ง๐ ๐“๐†๐…ฮฒ๐Ÿ‘ ๐ซ๐ž๐ ๐ฎ๐ฅ๐š๐ญ๐ž ๐๐ข๐Ÿ๐Ÿ๐ž๐ซ๐ž๐ง๐ญ ๐ ๐ž๐ง๐ž ๐ง๐ž๐ญ๐ฐ๐จ๐ซ๐ค๐ฌ, with TGFฮฒ1 demonstrating the largest genomic influence. Despite these differences, all three isoforms converged on critical biological pathways linked to metabolic reprogramming, cellular polarity, and Rap1 signalling โ€” mechanisms ๐ฌ๐ญ๐ซ๐จ๐ง๐ ๐ฅ๐ฒ ๐š๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ž๐ ๐ฐ๐ข๐ญ๐ก ๐ญ๐ฎ๐ฆ๐จ๐ฎ๐ซ ๐ฉ๐ซ๐จ๐ ๐ซ๐ž๐ฌ๐ฌ๐ข๐จ๐ง, ๐ฆ๐ž๐ญ๐š๐ฌ๐ญ๐š๐ฌ๐ข๐ฌ, ๐š๐ง๐ ๐๐ซ๐ฎ๐  ๐ซ๐ž๐ฌ๐ข๐ฌ๐ญ๐š๐ง๐œ๐ž.

Importantly, the team identified several ๐ฉ๐ซ๐จ๐ฆ๐ข๐ฌ๐ข๐ง๐  ๐ฉ๐ซ๐จ๐ ๐ง๐จ๐ฌ๐ญ๐ข๐œ ๐›๐ข๐จ๐ฆ๐š๐ซ๐ค๐ž๐ซ๐ฌ, including CAMK2N1 and COL1A1, which were associated with ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ ๐ฌ๐ฎ๐ซ๐ฏ๐ข๐ฏ๐š๐ฅ ๐จ๐ฎ๐ญ๐œ๐จ๐ฆ๐ž๐ฌ and may contribute toward future precision medicine strategies in TNBC management.

This work highlights UMBIโ€™s continued contribution to advancing molecular oncology, translational medicine, and biomarker discovery research aimed at improving personalised cancer therapeutics and patient outcomes.

We invite colleagues and collaborators to explore the full study

Merafak sembah ucapan setinggi-tinggi tahniah kepada Kebawah Duli Yang Maha Mulia Seri Paduka Baginda Yang Di-Pertuan Ag...
31/05/2026

Merafak sembah ucapan setinggi-tinggi tahniah kepada Kebawah Duli Yang Maha Mulia Seri Paduka Baginda Yang Di-Pertuan Agong Sultan Ibrahim sempena Sambutan Ulang Tahun Hari Keputeraan Rasmi Kebawah Duli Yang Maha Mulia Seri Paduka Baginda Tuanku.

Seluruh Pengurusan Tertinggi dan Warga UMBI mendoakan ke hadrat Allah SWT semoga Kebawah Duli Yang Maha Mulia Tuanku sentiasa dikurniakan rahmat dan hidayah-Nya serta berada dalam keadaan sihat, sejahtera dan penuh kedaulatan.

Daulat Tuanku.


Seluruh warga UMBI mengucapkan selamat merayakan Sambutan Hari Wesak 2026 kepada semua penganutnya. Semoga sambutan ini ...
30/05/2026

Seluruh warga UMBI mengucapkan selamat merayakan Sambutan Hari Wesak 2026 kepada semua penganutnya. Semoga sambutan ini membawa kedamaian, ketenteraman, dan kebahagiaan kepada semua.


๐ŸŽ“ ๐๐ก๐ƒ ๐•๐ข๐ฏ๐š ๐•๐จ๐œ๐ž ๐€๐œ๐ก๐ข๐ž๐ฏ๐ž๐ฆ๐ž๐ง๐ญCongratulations to ๐Œ๐ฌ. ๐€๐Ÿ๐ซ๐ž๐ž๐ง๐š ๐€๐Ÿ๐ข๐ช๐š๐ก ๐€๐ณ๐ฆ๐š๐ง on successfully completing his ๐๐ก๐ƒ ๐•๐ข๐ฏ๐š ๐•๐จ๐œ๐ž ๐จ๐ง ๐Ÿ...
30/05/2026

๐ŸŽ“ ๐๐ก๐ƒ ๐•๐ข๐ฏ๐š ๐•๐จ๐œ๐ž ๐€๐œ๐ก๐ข๐ž๐ฏ๐ž๐ฆ๐ž๐ง๐ญ

Congratulations to ๐Œ๐ฌ. ๐€๐Ÿ๐ซ๐ž๐ž๐ง๐š ๐€๐Ÿ๐ข๐ช๐š๐ก ๐€๐ณ๐ฆ๐š๐ง on successfully completing his ๐๐ก๐ƒ ๐•๐ข๐ฏ๐š ๐•๐จ๐œ๐ž ๐จ๐ง ๐Ÿ๐Ÿ“ ๐Œ๐š๐ฒ ๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”!

Her doctoral research, entitled โ€œ๐…๐ฎ๐ง๐œ๐ญ๐ข๐จ๐ง๐š๐ฅ ๐‚๐ก๐š๐ซ๐š๐œ๐ญ๐ž๐ซ๐ข๐ณ๐š๐ญ๐ข๐จ๐ง ๐จ๐Ÿ ๐ฅ๐ง๐œ๐‘๐๐€ ๐“๐ˆ๐๐‚๐‘ ๐ข๐ง ๐“๐ฎ๐ฆ๐จ๐ฎ๐ซ ๐๐ซ๐จ๐ ๐ซ๐ž๐ฌ๐ฌ๐ข๐จ๐ง, ๐‚๐ก๐ž๐ฆ๐จ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ž๐ฎ๐ญ๐ข๐œ ๐‘๐ž๐ฌ๐ฉ๐จ๐ง๐ฌ๐ž ๐ข๐ง ๐ฏ๐ข๐ญ๐ซ๐จ ๐š๐ง๐ ๐‚๐ฅ๐ข๐ง๐ข๐œ๐š๐ฅ ๐Ž๐ฎ๐ญ๐œ๐จ๐ฆ๐ž ๐ข๐ง ๐“๐ซ๐ข๐ฉ๐ฅ๐ž-๐๐ž๐ ๐š๐ญ๐ข๐ฏ๐ž ๐๐ซ๐ž๐š๐ฌ๐ญ ๐‚๐š๐ง๐œ๐ž๐ซ (๐“๐๐๐‚)โ€, contributes valuable insights into the molecular mechanisms underlying TNBC and advances our understanding of potential biomarkers and therapeutic targets in breast cancer research.

We would also like to extend our sincere congratulations and appreciation to her supervisory team for their dedication, guidance, and mentorship throughout this academic journey:

The work was conducted under the supervision of:

โ€ข ๐ƒ๐ซ. ๐„๐ณ๐š๐ง๐ž๐ž ๐€๐ณ๐ฅ๐ข๐ง๐š ๐Œ๐จ๐ก๐š๐ฆ๐š๐ ๐‡๐š๐ง๐ข๐Ÿโ€“ Main Supervisor
โ€ข ๐€๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ž ๐๐ซ๐จ๐Ÿ๐ž๐ฌ๐ฌ๐จ๐ซ ๐“๐ฌ. ๐ƒ๐ซ. ๐‚๐ก๐ข๐ง ๐’๐ข๐จ๐ค ๐…๐จ๐ง๐  ๐š๐ง๐ ๐๐ซ๐จ๐Ÿ๐ž๐ฌ๐ฌ๐จ๐ซ ๐ƒ๐ซ. ๐๐จ๐ซ ๐…๐š๐๐ข๐ฅ๐š๐ก ๐‘๐š๐ฃ๐š๐› โ€“ Co-Supervisor

This achievement reflects the hard work, perseverance, and commitment of both the candidate and her supervisors. We wish Ms. Afreena continued success in her future academic and professional endeavors.

Seluruh Warga UMBI mengucapkan Selamat Menyambut Pesta Keamatan dan Hari Gawai kepada seluruh rakyat Malaysia yang merai...
29/05/2026

Seluruh Warga UMBI mengucapkan Selamat Menyambut Pesta Keamatan dan Hari Gawai kepada seluruh rakyat Malaysia yang meraikannya.

Kotobian Tadau Tagazo Do Kaamatan, Gayu Guru Gerai Nyamai!


โœจ๐ŸŒ™โœจ ๐’๐ž๐ฅ๐š๐ฆ๐š๐ญ ๐Œ๐ž๐ง๐ฒ๐š๐ฆ๐›๐ฎ๐ญ ๐‡๐š๐ซ๐ข ๐‘๐š๐ฒ๐š ๐€๐ข๐๐ข๐ฅ๐š๐๐ก๐š ๐Ÿ๐Ÿ’๐Ÿ’๐Ÿ•๐‡ โœจ๐ŸŒ™โœจ โ€œSesungguhnya solatku, ibadahku, hidupku dan matiku hanyalah untuk A...
26/05/2026

โœจ๐ŸŒ™โœจ ๐’๐ž๐ฅ๐š๐ฆ๐š๐ญ ๐Œ๐ž๐ง๐ฒ๐š๐ฆ๐›๐ฎ๐ญ ๐‡๐š๐ซ๐ข ๐‘๐š๐ฒ๐š ๐€๐ข๐๐ข๐ฅ๐š๐๐ก๐š ๐Ÿ๐Ÿ’๐Ÿ’๐Ÿ•๐‡ โœจ๐ŸŒ™โœจ

โ€œSesungguhnya solatku, ibadahku, hidupku dan matiku hanyalah untuk Allah, Tuhan seluruh alam.โ€
โ€” Surah Al-An'am, ayat 162

Semoga segala pengorbanan dan amal ibadah kita diterima Allah SWT.

Aidiladha mengajar kita erti keikhlasan, kesabaran dan ketaatan. Mari kita hayati semangat pengorbanan ini dalam kehidupan dan pekerjaan seharian.

Ikhlas daripada:
Seluruh Warga UMBI
27 Mei 2026 | 10 Zulhijjah 1447H

๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐’๐ฉ๐จ๐ญ๐ฅ๐ข๐ ๐ก๐ญ ๐๐จ.๐Ÿ‘/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”๐ƒ๐ž๐œ๐จ๐๐ข๐ง๐  ๐€๐Œ๐‹: ๐†๐ซ๐š๐ฉ๐ก-๐๐š๐ฌ๐ž๐ ๐Œ๐ž๐ญ๐ก๐จ๐ ๐Ÿ๐จ๐ซ ๐๐จ๐ญ๐ž๐ง๐ญ๐ข๐š๐ฅ ๐†๐ž๐ง๐ž ๐ƒ๐ข๐ฌ๐œ๐จ๐ฏ๐ž๐ซ๐ฒUMBI is pleased to share a...
26/05/2026

๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐’๐ฉ๐จ๐ญ๐ฅ๐ข๐ ๐ก๐ญ ๐๐จ.๐Ÿ‘/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ”

๐ƒ๐ž๐œ๐จ๐๐ข๐ง๐  ๐€๐Œ๐‹: ๐†๐ซ๐š๐ฉ๐ก-๐๐š๐ฌ๐ž๐ ๐Œ๐ž๐ญ๐ก๐จ๐ ๐Ÿ๐จ๐ซ ๐๐จ๐ญ๐ž๐ง๐ญ๐ข๐š๐ฅ ๐†๐ž๐ง๐ž ๐ƒ๐ข๐ฌ๐œ๐จ๐ฏ๐ž๐ซ๐ฒ

UMBI is pleased to share a recent publication from our researchers, led by Dr. Redha Abdullah, exploring novel genes associated with acute myeloid leukemia (AML) using a graph-based clustering approach and protein-protein interaction network analysis.

By analysing complex molecular interaction networks, the team identified ๐Ÿ๐Ÿ” ๐ฉ๐จ๐ญ๐ž๐ง๐ญ๐ข๐š๐ฅ ๐€๐Œ๐‹-๐š๐ฌ๐ฌ๐จ๐œ๐ข๐š๐ญ๐ž๐ ๐ ๐ž๐ง๐ž๐ฌ ๐ฌ๐ก๐จ๐ฐ๐ข๐ง๐  ๐ฌ๐ข๐ ๐ง๐ข๐Ÿ๐ข๐œ๐š๐ง๐ญ ๐๐ข๐Ÿ๐Ÿ๐ž๐ซ๐ž๐ง๐ญ๐ข๐š๐ฅ ๐ž๐ฑ๐ฉ๐ซ๐ž๐ฌ๐ฌ๐ข๐จ๐ง ๐š๐œ๐ซ๐จ๐ฌ๐ฌ ๐ฆ๐ฎ๐ฅ๐ญ๐ข๐ฉ๐ฅ๐ž ๐€๐Œ๐‹ ๐ฌ๐ฎ๐›๐ญ๐ฒ๐ฉ๐ž๐ฌ, including PML-RARฮฑ and CD34-positive AML. The findings revealed that these genes are ๐ฌ๐ญ๐ซ๐จ๐ง๐ ๐ฅ๐ฒ ๐ฅ๐ข๐ง๐ค๐ž๐ ๐ญ๐จ ๐ซ๐ข๐›๐จ๐ฌ๐จ๐ฆ๐ž ๐›๐ข๐จ๐ ๐ž๐ง๐ž๐ฌ๐ข๐ฌ, ๐ญ๐ซ๐š๐ง๐ฌ๐ฅ๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐œ๐จ๐ง๐ญ๐ซ๐จ๐ฅ, ๐œ๐ก๐ซ๐จ๐ฆ๐š๐ญ๐ข๐ง ๐จ๐ซ๐ ๐š๐ง๐ข๐ณ๐š๐ญ๐ข๐จ๐ง, ๐š๐ง๐ ๐ค๐ž๐ฒ ๐ฉ๐š๐ญ๐ก๐ฐ๐š๐ฒ๐ฌ such as PI3K/AKT signalling and hematopoietic dysregulation.

Importantly, this systems-level approach provides new insights into the molecular mechanisms underlying AML progression and highlights several candidate genes that may serve as future biomarkers or therapeutic targets for this aggressive blood cancer. The study also demonstrates the ๐ฉ๐จ๐ญ๐ž๐ง๐ญ๐ข๐š๐ฅ ๐จ๐Ÿ ๐ ๐ซ๐š๐ฉ๐ก-๐›๐š๐ฌ๐ž๐ ๐œ๐จ๐ฆ๐ฉ๐ฎ๐ญ๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐›๐ข๐จ๐ฅ๐จ๐ ๐ฒ in advancing precision diagnostics and personalised treatment strategies in hematological malignancies.

These findings further reflect UMBIโ€™s growing strength in molecular oncology, bioinformatics, systems biology, and translational cancer research aimed at improving disease understanding and patient outcomes.

We invite colleagues and collaborators to explore the full study:

Muhamad Azuan et al. Oncologie (2026)

22 May 2026 - The weekly ๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐”๐ฉ๐๐š๐ญ๐ž ๐’๐ž๐ซ๐ข๐ž๐ฌ ๐ข๐ง ๐Œ๐จ๐ฅ๐ž๐œ๐ฎ๐ฅ๐š๐ซ ๐Œ๐ž๐๐ข๐œ๐ข๐ง๐ž ๐๐จ. ๐Ÿ๐Ÿ‘/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ” featured two insightful presentat...
26/05/2026

22 May 2026 - The weekly ๐”๐Œ๐๐ˆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐”๐ฉ๐๐š๐ญ๐ž ๐’๐ž๐ซ๐ข๐ž๐ฌ ๐ข๐ง ๐Œ๐จ๐ฅ๐ž๐œ๐ฎ๐ฅ๐š๐ซ ๐Œ๐ž๐๐ข๐œ๐ข๐ง๐ž ๐๐จ. ๐Ÿ๐Ÿ‘/๐Ÿ๐ŸŽ๐Ÿ๐Ÿ” featured two insightful presentations by UMBI Research Fellows, highlighting the dynamic landscape of scientific research, innovation and adaptability in molecular medicine.

The first session by Assoc. Professor Dr. Nadiah Abu titled โ€œ๐“๐ก๐ž ๐€๐ง๐š๐ญ๐จ๐ฆ๐ฒ ๐จ๐Ÿ ๐€๐๐š๐ฉ๐ญ๐š๐ญ๐ข๐จ๐ง โ€“ ๐๐ข๐ฏ๐จ๐ญ๐ข๐ง๐  ๐ข๐ง ๐’๐œ๐ข๐ž๐ง๐œ๐žโ€ explored the evolving nature of scientific careers and the importance of strategic adaptability in research. Her presentation discussed the concept of intellectual freedom, structural pillars of academic survival, and the many dimensions of research pivoting including hypothesis, methodological, model-system, career and translational pivots. Drawing from notable scientific success stories such as the discovery journey of Minoxidil, Dr. Nadiah also shared important reflections on โ€œpivot penaltiesโ€, the Dunning-Kruger Effect, Nobel Disease, and the challenges faced by non-pivoters. She further inspired the audience through her personal experience in securing the ๐‹๐จ๐ง๐ -๐“๐ž๐ซ๐ฆ ๐‘๐ž๐ฌ๐ž๐š๐ซ๐œ๐ก ๐†๐ซ๐š๐ง๐ญ ๐’๐œ๐ก๐ž๐ฆ๐ž (๐‹๐‘๐†๐’) ๐Ÿ๐ซ๐จ๐ฆ ๐ญ๐ก๐ž ๐Œ๐ข๐ง๐ข๐ฌ๐ญ๐ซ๐ฒ ๐จ๐Ÿ ๐‡๐ข๐ ๐ก๐ž๐ซ ๐„๐๐ฎ๐œ๐š๐ญ๐ข๐จ๐ง (๐Š๐๐“). The session concluded with a meaningful take-home message that the best scientists are often those who know when to persist and when to pivot.

The second session was delivered by Ts. Dr. Aiman Mohtar entitled โ€œ๐…๐ซ๐จ๐ฆ ๐’๐œ๐ข๐ฌ๐ฌ๐จ๐ซ๐ฌ ๐ญ๐จ ๐’๐ž๐ง๐ฌ๐จ๐ซ๐ฌ: ๐‚๐‘๐ˆ๐’๐๐‘ ๐š๐ฌ ๐š ๐๐ฅ๐š๐ญ๐Ÿ๐จ๐ซ๐ฆ ๐Ÿ๐จ๐ซ ๐ƒ๐ข๐ฌ๐œ๐จ๐ฏ๐ž๐ซ๐ฒ, ๐ƒ๐ข๐š๐ ๐ง๐จ๐ฌ๐ญ๐ข๐œ๐ฌ ๐š๐ง๐ ๐“๐ก๐ž๐ซ๐š๐ฉ๐ž๐ฎ๐ญ๐ข๐œ๐ฌโ€. The presentation provided a comprehensive overview of CRISPR technology, tracing its origins from bacterial immune defense systems to one of the most transformative tools in biotechnology. The audience gained insights into how scientists repurposed the bacterial memory spacer system into synthetic guide RNA technology, enabling broad applications across multiple fields. Dr. Aimanuddin highlighted the growing impact of CRISPR in plant biotechnology, livestock improvement, genetic and metabolic disease correction, infectious disease control, drug discovery, biofuel production and the food industry. He also shared updates on CRISPR therapeutics currently in clinical trials, alongside ongoing UMBI research applications including targeted gene knockout studies in breast cancer cells and CRISPRi genetic screening targeting upregulated cell surface genes in glioblastoma (GBM).

The session reflected UMBIโ€™s continued commitment towards advancing molecular medicine research and fostering a culture of scientific excellence and collaboration. Appreciation is extended to both speakers for their informative and engaging sharing sessions, as well as to all participants for their active participation and encouraging discussions throughout the programme.

Address

Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)
Kuala Lumpur
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