Sociedad Mexicana de Proteómica

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Organización Civil sin fines de lucro, cuyo objetivo es impulsar el desarrollo de la investigación proteómica y metabolómica en México usando como herramienta fundamental la Espectrometría de Masas.

The ecological interaction between plants and herbivores has promoted the evolution of defense and offense ch...
27/05/2026










The ecological interaction between plants and herbivores has promoted the evolution of defense and offense characteristics of both parties. Specialized metabolites, including volatile organic compounds (VOCs), constitute a key defensive mechanism of plants, helping to reduce/prevent damage by herbivores and indirectly attracting their natural enemies. However, in the absence of herbivores, as occurs in invaded ranges, natural selection may favor the reduction in costly chemical defenses. Here, we assessed the production of VOCs in both damaged and undamaged leaves of plants of Datura stramonium from Mexico (native) and Spain (non-native). The emissions of VOCs were detected and compared, along with the induction extended to neighboring undamaged leaves. A total of 45 VOCs were detected and differences in chemical diversity and concentration between plants of different origin and between damaged and undamaged leaves. Notably, native populations exhibited greater VOCs diversity and higher emission levels than non-native populations, highlighting population-specific differences in both constitutive and induced chemical defenses. Expression analysis of the gene implicated in terpenoid biosynthesis (DsTPS10) demonstrated damage-induced upregulation. Gene expression patterns coupled with metabolic profiles suggest a potential defense capability of native populations as compared with non-native populations of recent evolution in the absence of the D. stramonium’s coevolved herbivores

https://www.mdpi.com/2223-7747/15/10/1501

Fructans play important roles in plant physiology and have been reported to have several technological applicatio...
25/05/2026








Fructans play important roles in plant physiology and have been reported to have several technological applications. They are complex fructose oligo- and polysaccharides with varying Degrees of Polymerization (DPs) and branching types. These features have made it difficult to determine the structure of the plant's different isomers. This work introduces a combined experimental and computational approach, in which we compare experimentally derived Collision Cross-Section (CCSe) values with a computationally generated CCS (CCSt) database of potential fructans based on reported characteristics. We identified 34 CCSe values corresponding to fructans up to DP12, of which 24 (70%) matched entries in the CCSt database with an average error of 0.29%, and were successfully assigned a structure. This approach offers promising possibilities for analysing different molecules and sample types.

https://www.sciencedirect.com/science/article/pii/S014486172600528X

Synthetic dyes, widely used in the textile industry, exhibit high stability and low biodegradability, cont...
22/05/2026











Synthetic dyes, widely used in the textile industry, exhibit high stability and low biodegradability, contributing to the contamination when they reach natural water bodies and representing a major environmental challenge. In this study, forest residues from Dalbergia congestiflora and Peltogyne mexicana, with Tezontle as a reference material, were evaluated as bioactive biocarriers for the degradation of Reactive Black 5 and Remazol Brilliant Blue R in a haloalkaline system. Decolorization efficiencies >85% were achieved under microaerobic conditions (static, non-aerated system); however, mineralization and toxicity depended on the dye type, aeration regime, and selected biocarrier. P. mexicana exhibited the highest mineralization, with inorganic carbon (IC) values of approximately 11.3 mg L−1, together with higher median inhibitory concentration values (IC50 ≈ 0.16 mg L−1) and a higher mitotic index (MI ≈ 10%), indicating a more efficient biofilm and effluents with lower toxicity. Tezontle and D. congestiflora exhibited IC < 6 mg L−1, IC50 < 0.15 mg L−1, and MI < 9%, reflecting lower mineralization and detoxification. Metabolite analysis using high-resolution mass spectrometry enabled the identification of the degradation pathways for both dyes. Structural and microbial differences among the biocarriers, inferred from detailed analyses of their architecture and biofilm community profiles at the end of treatment, revealed differences associated with the type of biocarrier, which may explain the variability in the degradative activity and effluent detoxification. These findings provide exploratory evidence that forest residues, particularly P. mexicana, as bioactive and efficient biocarriers, promoting specialized microbial consortia and improving dye transformation during textile wastewater detoxification.

https://www.sciencedirect.com/science/article/pii/S147470652600224X

Amoebiasis is a gastrointestinal infection caused by the protozoan parasite Entamoeba histolytica (E. histolyti...
19/05/2026










Amoebiasis is a gastrointestinal infection caused by the protozoan parasite Entamoeba histolytica (E. histolytica, Eh) and remains one of the leading parasitic causes of human mortality worldwide. Invasive intestinal disease may present with abdominal cramping, abdominal pain, watery or bloody diarrhea, and weight loss. Understanding the factors that modulate parasite virulence is therefore essential to elucidate disease pathogenesis.
The E. histolytica genome encodes two low-molecular-weight protein tyrosine phosphatases (LMW-PTPs), EhLMW-PTP1 and EhLMW-PTP2, whose roles in parasite virulence remain poorly understood. Here, we investigated the molecular interactions of EhLMW-PTP2 using in vitro assays with recombinant wild-type protein and its catalytic mutant. Pull-down assays and co-immunoprecipitation coupled with LC–MS/MS were performed to identify candidate proteins associated with EhLMW-PTP2 following fibronectin stimulation. Selected interactors, including EhCP5 and EhCBP, were further analyzed in trophozoites overexpressing EhLMW-PTP2, where reduced transcript and protein levels were observed.
Parasites overexpressing EhLMW-PTP2 exhibited reduced migratory capacity and caused less liver damage in infected hamsters, consistent with previous observations of decreased phagocytosis and cytopathic activity. Notably, these effects were observed independently of catalytic site integrity in vivo. Our results indicate that EhLMW-PTP2 is associated with protein interaction networks that include factors linked to transcriptional processes, cytoskeletal organization, and vesicular trafficking. However, these findings should be interpreted as associations, and their contribution to the reduced virulence phenotype remains to be determined.

https://www.sciencedirect.com/science/article/pii/S0001706X26001622?via%3Dihub

Maternal obesity is increasingly recognized as an important modulator of early-life microbial and metaboli...
15/05/2026













Maternal obesity is increasingly recognized as an important modulator of early-life microbial and metabolic environments. This study investigates the association between maternal body mass index (BMI) and the microbiota and metabolite profiles of colostrum and neonatal f***s in a Mexican mother–infant cohort. Milk and f***l samples were collected from dyads of obese and normal-weight mothers. Bacterial microbiota composition was characterized by sequencing the 16 S rRNA gene (V3 region) using Ion Torrent technology, and metabolomic profiling was performed using Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. The results provide evidence consistent with vertical microbial and metabolic transmission, with Firmicutes and Patescibacteria predominating in Colostrum. Neonates born to obese mothers exhibited reduced relative abundances of Lactobacillus in neonatal f***l samples, alongside increased levels of Lactobacillus and Staphylococcus in both colostrum and mother´s f***s. Overall microbial diversity across maternal stool, colostrum, and neonatal stool samples was not significantly associated with maternal BMI; however, distinct metabolite signatures linked to maternal obesity, like oligopeptides, glycoside-related compounds, Phosphatidic Acid (PA) Derivatives, bioactive molecules such as enkephalinamide derivatives, were observed. These findings highlight the role of breastfeeding as a key interface in shaping the neonatal gut microbiota and metabolome and suggest potential pathways linking maternal metabolic status with early-life microbial and metabolic programming. This study advances understanding of maternal–infant microbial ecology and supports further investigation into the long-term health implications of maternal obesity.

https://www.nature.com/articles/s41598-026-49183-x

The most common ocular neoplasia among children is retinoblastoma. Currently, the diagnosis of this disease...
14/05/2026











The most common ocular neoplasia among children is retinoblastoma. Currently, the diagnosis of this disease is essentially clinical, taking a biopsy is contraindicated owing to the high risk of causing metastasis. Therefore, it is imperative the development of a method to diagnose this disease through a non-invasive fashion. We choose tears as they fulfill the former precept. Through proteomic analysis we observed 52 up regulated and 48 down regulated proteins among retinoblastoma cases as compared to healthy children. Among these proteins, we identified several previously associated with retinoblastoma such as apolipoprotein A-1 (APOA1). We confirmed up regulation of APOA1 and S100 binding calcium A9 (S100A9) which revealed faithful concordance to the predicted values from mass spectrometry.

https://www.journalofliquidbiopsy.com/article/S2950-1954(26)00017-2/fulltext

Breast cancer, the leading cause of death in women worldwide, shows significant heterogeneity that makes this ...
11/05/2026











Breast cancer, the leading cause of death in women worldwide, shows significant heterogeneity that makes this disease extremely difficult to treat. Many reports point to metabolic shifts, mainly those carried out into mitochondria, as key processes governing the behavior and heterogeneity of several types of breast cancer. In this study, we performed label-free proteomics analysis on mitochondria-enriched fractions from T47D and MDA-MB-231 breast cancer cell lines, which have distinct molecular classifications, using bioinformatics analyses to identify differentially expressed proteins compared to MCF-12F healthy breast cells. Cancer cells exhibited down-regulated protein levels of subunits from the respiratory chain's Complex I. However, both showed differentially abundant proteins involved in ligase and oxidoreductase activities, including enzymes of glycolysis, pyruvate metabolism, the Krebs cycle, and gluconeogenesis. Many of these enzymes also participate in other metabolic processes, such as mitochondrial localization, mitochondrial gene expression, and the metabolism of amino acids, fatty acids, purines, and pyrimidines. Gene Set Enrichment Analysis revealed that OXPHOS subunits are integrated as signatures of neurodegenerative disease pathways. A protein set with little or no evidence in breast cancer was identified, which could lead to future research in breast cancer mitochondrial metabolism. Data are available via ProteomeXchange with identifier PXD069883. Significance: This manuscript determined the protein expression profiles of mitochondria-enriched fractions from T47D (Luminal A, stage IV) and MDA-MB-231 (triple negative, Stage IV) breast cancer cell lines compared to the MCF-12F healthy breast cell line. We found that breast cancer cell lines exhibited low expression levels of Complex I subunits from the respiratory chain. However, both breast cancer cell lines presented high expression levels of some proteins related to ligase and oxidoreductase activities, the latter on CH-OH groups in cellular respiration processes, such as some enzymes from glycolysis, pyruvate metabolism, Krebs cycle and gluconeogenesis. Moreover, many of these enzymes also participate in other metabolic processes, such as localization to the mitochondrion, mitochondrial gene expression, amino acid, fatty acid, purine, and pyrimidine metabolism. We also observed through Gene Set Enrichment Analysis that OXPHOS enzymes have a key role in many neurodegenerative disease pathways as well. Finally, we found a protein set with little or no evidence in breast cancer that could lead to future pivotal research in the mitochondrial metabolism of breast cancer

https://www.sciencedirect.com/science/article/pii/S1874391926000643

Amaranth is a nutrient-rich pseudocereal valued for its high protein content and bioactive compounds with anti...
07/05/2026










Amaranth is a nutrient-rich pseudocereal valued for its high protein content and bioactive compounds with antioxidant properties. This study investigated the effects of salicylic acid (SA) and hydrogen peroxide (H₂O₂) elicitors, imbibition time (2–8 h), and germination duration (72–120 h) on the bioactive compounds in amaranth sprouts. A factorial design with varying elicitor concentrations (0–340 ppm H₂O₂, 0–11 ppm SA) was used. Bioactive compounds and antioxidant activity (ABTS, DPPH, FRAP) were quantified spectrophotometrically, and phenolic profiling was performed via FIA-ESI-FTICR-MS. Germination significantly increased phenolics and betalains. SA (5.5 ppm) and H₂O₂ (340 ppm) enhanced phenolics and flavonoids, while longer germination (120 h) maximized betalains. Antioxidant activity, determined by the ABTS assay, increased by up to 3.69-fold relative to raw amaranth (p < 0.05). Elicitation elevated quercetin, kaempferol, and betaxanthin levels. SA was particularly effective. These findings support the use of elicitation to enhance amaranth's functional properties for food and nutraceutical applications.

https://www.sciencedirect.com/science/article/pii/S2772502226003574

La Sociedad Mexicana de Proteómica se complace en invitarlos a su 10.º simposio “MultiOmics and Integrative Biology: Adv...
07/05/2026

La Sociedad Mexicana de Proteómica se complace en invitarlos a su 10.º simposio “MultiOmics and Integrative Biology: Advances and Applications”, que se celebrará en la ESIQIE del IPN, en la Ciudad de México, del 9 al 13 de noviembre de 2026. Contaremos con la participación de excelentes ponentes nacionales e internacionales, así como con cursos y talleres. Pueden consultar más detalles en: https://www.smp.org.mx/xsymposium/

The Mexican Proteomics Society is pleased to invite you to its 10th Symposium, “MultiOmics and Integrative Biology: Advances and Applications,” which will be held at ESIQIE-IPN in Mexico City from November 9 to 13, 2026. The event will feature excellent national and international speakers, as well as courses and workshops. Further details are available at: https://www.smp.org.mx/xsymposium/

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