06/06/2026
Researchers have developed a new biological clock that uses RNA activity to estimate how far aging has progressed and how strongly it may be linked to mortality risk.
The tool is called a transcriptomic clock. Instead of looking at DNA methylation marks, it studies RNA molecules that show which genes are switched on or off in cells and tissues.
The study, DOI 10.1038/s41586-026-10542-3, analyzed more than 11,000 samples from mice, rats, macaques, and humans across more than 25 tissue types. The researchers found that many aging signals were shared across species and organs, including blood, muscle, liver, and heart tissue.
Genes involved in healthy cell division and wound repair were linked with slower molecular aging. Genes tied to inflammation and cell death were linked with faster aging and higher biological age.
In human blood samples, the clock could estimate time to death about as well as leading epigenetic clocks. It also detected aging patterns connected with chronic disease in animal models and human patient tissue samples.
The clock cannot tell a person the exact date they will die. Its value is as a research tool that may help scientists measure biological aging, compare aging across species, and test whether lifestyle changes, disease, pollution, or possible treatments appear to speed up or slow down aging.
More testing is still needed, especially in larger and more diverse human populations. But the results suggest that gene activity may reveal common biological patterns of aging that are conserved across mammals.