Master Of Pharmacy_4th Batch_General_UODA

Master Of Pharmacy_4th Batch_General_UODA UODA_Master of pharmacy 4th batch (General)

11/02/2016

This is for the information of m.pharm batch 03,04, 05,06 , and 07 that they can attend convocation (HELD ON 25.02.2016) if they registrar by paying registration fees by 15th february to registrars office. Office will remain open tomorrow (FRIDAY). Pls inform this message to all students.

Atiq
Coordinator, M.Pharm.

30/10/2015

10 definitions of different types of dose

Therapeutic or effective dose: The dose which will produce optimum therapeutic effect.

Toxic dose: Excess dose which will produce serious toxic effect.

Booster dose: A dose which is given after sometimes of an initial dose to enhance the effect. Example: anti tetanus, anti poliomyelitis

Test dose: Amount of drug which is given at first to test the response of tissue to the drug.

Minimal dose: Minimum quantity of drug which is required to produce certain desirable effect.

Maximal dose: Maximum quantity of drug which can be given without producing toxic effect.

Adult dose: According to British pharmacopoeia the dose for the patient in between 20-60 years of age is adult dose. If age is below 20 years or above 60 years dose should be reduce.

Maintenance dose: Is one that is to be repeated at specified intervals after the attainment of target plasma concentration. So as to maintain the same by balancing elimination.

Fatal dose: The dose which causes death of hundred percent test animals.

Lethal dose: The dose that likely to causes death of certain percentage of test animals.

13/05/2015

যারা প্রজেক্ট ভাইভা দিবেন তারা এখনই নিজের নাম, আইডি এবং সুপারভাইজারের নাম লিখে আতিক স্যার কে sms করুন।আজকের মধ্যে অব্যশই sir কে sms পাঠাবেন।

05/05/2015

Notice for Project viva:

The students who want to participate in the viva exam are requested to list their name within 06.05.2015 either comming or by phone.
Unlisted students will not be permitted.

Atiq
Coordinator

12/03/2015

Class & Class test Schedule :

>>> Friday (13 March, 2015)

>>>9:00 am>>> Pharmaceutical Marketing & Sales>>>Moshiur sir

>>>11:00 am>>> Drug use management & Toxicology>>>Class test + Review class>>>Zubaida mam

11/03/2015

>>>Class test & Assignment info:

>>>Subject : Drug use management & toxicology

>>>Class test schedule : 13-03-2015 (Friday)

>>>Class test topic : Adverse Drug Reactions(ADRs)

>>>Assignment info :

>>>Subject : Drug use management & Toxicology

>>>Submission Date : 20-03-2015( Friday)

>>>Assignment topics :

>>>For ID (even number)

1.Drug induced liver toxicity
2.Perspective of Antibiotic registance in Bangladesh.

>>>For ID (odd number)

1.Drug induced nephro-toxicity
2.Perspective of Metal toxicity in Bangladesh.

*****N.B. :
1.Assignment compose করতে হবে।
2.Punch file এ দিতে হবে।
3. Liver, Kidney এর বর্ণনা দিতে হবে।বিশেষ করে liver, kidney'র function.
4.যেসব drug liver, kidney ওপর toxicity show করে তাদের list দিতে হবে।
5. Assignment গুলো বাংলাদেশের perspective এ করতে হবে। field level এর কোনো কাজ সংযুক্ত করতে পারলে নাম্বার বেশি পাওয়া যাবে।

08/03/2015

Mechanism of action of Aspirin :

The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Acetylsalicylic acid directly and irreversibly inhibits the activity of both types of cyclooxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes acetylsalicylic acid different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Acetylsalicylic acid's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation-inhibiting effect of acetylsalicylic acid specifically involves the compound's ability to act as an acetyl donor to cyclooxygenase; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Irreversible acetylation renders cyclooxygenase inactive, thereby preventing the formation of the aggregating agent thromboxane A2 in platelets. Since platelets lack the ability to synthesize new proteins, the effects persist for the life of the exposed platelets (7-10 days). Acetylsalicylic acid may also inhibit production of the platelet aggregation inhibitor, prostacyclin (prostaglandin I2), by blood vessel endothelial cells; however, inhibition prostacyclin production is not permanent as endothelial cells can produce more cyclooxygenase to replace the non-functional enzyme.

Reference : Drug Bank

18/02/2015

Drug:

Any substance that is used or intended to be used to modify or explore physiological system or pathological states for the benefit of the recipient.

18/02/2015

>>>Definition of Pharmacology:

>>>Science of drug which deals with details study of source, chemical nature, route of administration, absorption, distribution, pharmacological effect, metabolism, excretion and side effect or adverse reaction of drugs.

17/02/2015

Definition of Dissolution :

Dissolution is pharmaceutically defined as the rate of mass transfer from a solid surface into the dissolution medium or solvent under standardized conditions of liquid/solid interface, temperature and solvent composition. It is a dynamic property that changes with time and explains the process by which a homogenous mixture of a solid or a liquid can be obtained in a solvent. It happens to chemically occur by the crystal break down into individual ions, atoms or molecules and their transport into the solvent.

17/02/2015

Dissolution apparatuses(United States Pharmacopeia):

• USP Dissolution Apparatus 1 - Basket (37°C)

• USP Dissolution Apparatus 2 - Paddle (37°C)

• USP Dissolution Apparatus 3 - Reciprocating Cylinder (37°C)

• USP Dissolution Apparatus 4 - Flow-Through Cell (37°C)

USP Dissolution Apparatus 2 is the most widely used apparatus among these four.

USP Paddle method:

It is also called USP apparatus-2, the paddle should be centered within 0.2 cm of the centerline of the vessel, 2.5 + 0.2 cm from the bottom of the vessel. the shaft should rotate at a spped of 100 rpm with a temperature of about 37 0 C. the dosage form should experience some movement under the paddle till disintegration progresses. once disintegration occurs, aliquots should be drawn preferably from midway upper endge of the paddle and the surface of the medium between the wall of the vessel and stirrer shaft. the lowwer portion of vessel should be hemispherical and uniform in all aspects of weight, inside diameter and curvature.in case of floating dosage forms statinless steel or glass helix is attached to the dosage form. in this case excess abrasion and wear of the doage forms due to the friction from the inner surfaces is observed, affecting the micro environment adversely.

17/02/2015

What is Tablet Dissolution Testing?

A dissolution test is a means of identifying and proving the availability of active drug materials in their delivered form. A dissolution test simulates the availability of active substance and allows the prediction of the time for complete release of the material from the dosage form.

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