31/08/2026
Why does inflammatory bowel disease (IBD) continue to flare-up despite patients having symptoms under control? 🔬
A new study by the Royal Melbourne Hospital (RMH) and WEHI - Walter and Eliza Hall Institute of Medical Research has uncovered a hidden process that may help explain why IBD can return, even when patients appear to be doing well.
The findings, which were recently published in the prestigious Science magazine, suggest IBD can remain active beneath the surface in the lining of the gut.
Inflammatory bowel disease (IBD), which includes conditions such as Crohn’s disease and ulcerative colitis, is a chronic condition affecting around 180,000 Australians.
Symptoms can be severe and may include abdominal pain, diarrhoea, fatigue and weight loss.
While modern treatments can help many people reach remission, IBD remains difficult to diagnose and treat.
Co-author of the study, RMH gastroenterologist Dr Aysha Al-Ani, says the new findings provide a strong foundation for future work, including new treatments and therapeutics.
"It opens new avenues for different prognostic tools, using more sophisticated and refined methods than are currently used clinically,” she says.
“The ethos behind IBD therapy is to reduce the frequency and severity of flares, halting disease progression and improving patients’ lives.
“More sensitive molecular detection may help us keep patients in deep remission for longer and introduce new treatments.”
📸: Patterns of cell death-related genes in gut tissue from people with inflammatory bowel disease
More information can be found at: https://f.mtr.cool/693rxkabx0